I'm just using a small GTX 1060 3GB card which works just fine for 1080p 60Hz gaming. Yeah that might be a bit much for a RX 580 to handle. It'll be interesting to see how well it runs it. I'm interested to see how the 5700 series ends up being. You might want to wait until (I think it's early July when those cards launch) the reviews start coming out to see what to do. I'm wondering if maybe the Radeon 7 might be the card to go with especially if you want to go high settings/60Hz at that high of a resolution. I'm assuming that monitor has freesync and stuff like that right?